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The misery index is an economic indicator that defined by economist Arthur Okun in the late of decade 1970. This index, determine of total inflation and unemployment rates and express in terms of percent. High misery index, end in economic and public troubles. Because have increased both inflation and unemployment rates. In other words, the Misery index can indicate the state of stagflation in society. Thus, this study purpose, investigated the effective factors on misery index in selected provinces of the country (Markazi, Hamedan, Kermanshah, Kordestan and Lorestan) between years 2008-2018. Was estimated the effect of gross domestic product, commerce balance and tax independent variables and economic sanctions dummy variable on misery index dependent variable in a logarithmic model, the using of Eviews software and GMM Panel method. For this purpose, the relevant data were collected from the statistics center of Iran and the economic deputies of economic and financial affairs directorate general of mentioned province and after of statistical tests, determined commerce balance, gross domestic product and economic sanctions variables have significant and positive impact and tax variable has significant and negative impact on misery index.