Securities market and currency market have always been considered sensitive parts of financial market. The relationship between exchange rate changes caused by stock prices and price-to-earnings ratio was investigated in this study by using structural equation modeling method accompanied by partial least squares approach. The primary hypothesis was about the existence significant and positive relationship between exchange rate changes (Dollar and Euro) caused by stock prices and price-to-earnings ratio. The sample of study included 49 companies listed in stock exchange. They were selected at random. The time periods included 132 days studied from March 2012 until February 2012. The size of 49-sample was a total of 6468 institute-days. The findings indicated that there was a positive and significant relationship between exchange rate changes caused by stock prices and P/E ratio in Iran’s financial market.